Royal Air Force Typhoon FGR4s have joined forces with French aircraft in a coordinated attack on an underground arms cache in Syrian territory employed by the IS group, per a report from the UK Ministry of Defence.
The location, located using intelligence, was believed to be housing weapons and explosive materials, the announcement noted, and was situated in hills just north of the historic site of Palmyra in Syria's central region.
"Our fighter planes employed Paveway IV guided bombs to target a several entry passages providing entry to the site... early reports are that the target was engaged successfully," the MoD said.
There was no indication of any civilian casualties in the operation on Saturday evening and all the aircraft returned safely, the MoD added.
The British jets were assisted by a Voyager tanker plane.
IS - alternatively referred to as Daesh - imposed militant control over parts of Iraq and Syria prior to its 2019 collapse.
"This action shows our UK leadership, and commitment to operate in unison with our allies, to stamp out any revival of the terrorist group and their violent and radical beliefs in the Middle East," UK Defence Secretary John Healey said.
RAF aircraft have conducted overwatch operations over Syria to "forestall any attempted resurgence" of IS following its defeat at the Baghuz confrontation in 2019, the ministry said.
"I must thank the personnel of the UK armed forces who took part in this operation for their skill and their bravery," he added. "They were part of numerous UK service members deployed over the holidays. This action, to eliminate militants who pose a risk to our safety, shows how UK forces are always on standby, continuously, ensuring Britain's security within its borders and powerful internationally."
During December, the American forces conducted what it termed a "massive strike" targeting Daesh sites in Syria, subsequent to an assault claimed the lives of two US troops and a local interpreter in Palmyra.
The United Nations estimates IS still boasts between 5,000 and 7,000 militants in both countries.